You must check Keep all drugs out of the reach of children and pets. Monitoring requirements. Avoid combination, Vaccines (Live): Immune Globulins may diminish the therapeutic effect of Vaccines (Live). It may be given to you for other reasons. Antithymozytenglobulin (ATG) ist ein immunsuppressiv wirkendes Gemisch polyklonaler Antikörper, welches meist zur Therapie von Abstoßungsreaktionen nach Organtransplantation eingesetzt wird. Talk with your doctor. Check with your pharmacist. Severe and unremitting hemolysis may require treatment discontinuation. Two antithymocyte globulin (ATG) agents licensed for clinical use in the United States are Thymoglobulin (rabbit ATG, rATG, Genzyme) and Atgam (equine ATG, eATG, Pfizer). fever, chills, body aches, flu symptoms, unusual weakness or tired feeling; nausea, upper stomach pain, itching, loss of appetite; pain, swelling, warmth, or redness in one or both legs. Select one or more newsletters to continue. Use of immunosuppressants after administration of nivolumab (eg, for immune-related toxicity) is unlikely to affect nivolumab efficacy. [3] Consider therapy modification, Dermatologic: Dermatological reaction (wheal/flare), pruritus, skin rash, urticaria, Hematologic & oncologic: Leukopenia, thrombocytopenia, Cardiovascular: Bradycardia, cardiac disease, cardiac failure, chest pain, edema, hypertension, hypotension, myocarditis, phlebitis, thrombophlebitis, Central nervous system: Agitation, brain disease (viral), burning sensation (burning of soles and burning of palms), dizziness, encephalitis, generalized ache, lethargy, seizure, Gastrointestinal: Diarrhea, nausea, stomatitis, vomiting, Hepatic: Abnormal hepatic function tests, hepatosplenomegaly, Hypersensitivity: Anaphylaxis, serum sickness, Local: Injection site reaction (pain, redness, swelling), Neuromuscular & skeletal: Back pain, joint stiffness, myalgia, Respiratory: Dyspnea, pleural effusion, respiratory distress, <1%, postmarketing, and/or case reports: Abdominal pain, acute renal failure, anaphylactoid reaction, anemia, apnea, confusion, cough, deep vein thrombosis, disorientation, dizziness, eosinophilia, epigastric pain, epistaxis, erythema, flank pain, gastrointestinal hemorrhage, gastrointestinal perforation, granulocytopenia, hemolysis, hemolytic anemia, herpes simplex infection (reactivation), hiccups, hyperglycemia, infection, involuntary body movements, laryngospasm, malaise, muscle rigidity, neutropenia, pancytopenia, paresthesia, pulmonary edema, pure red cell aplasia, renal artery thrombosis, sore mouth, sore throat, tachycardia, thrombosis of vein (iliac), toxic epidermal necrolysis, tremor, vasculitis, viral hepatitis, weakness, wound dehiscence. View the formulary and any restrictions for each plan. Consider testing initially with an epicutaneous prick of undiluted antithymocyte globulin (ATG); if no wheal in 10 minutes, then use 0.02 mL intradermally of a 1:1000 dilution of ATG in normal saline along with a separate saline control of 0.02 mL; observe in 10 minutes. Talk with the doctor. In other words, patients who took horse ATG had increased blood counts, and the counts stayed up longer when compared to patients given rabbit ATG. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Discontinue if severe and unremitting leukopenia or thrombocytopenia occur in solid organ transplant patients. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. [2] Most commonly, these are "preferred" (on formulary) brand drugs. The first report of immunizing an animal of one species (Guinea pig) against the immune cells of another species (mouse lymphocytes) was by Élie Metchnikoff in 1899. IMPORTANT: Guidance for Bone Marrow Failure Patients to Protect Against Coronavirus (COVID-19) ». Generic Name: Antithymocyte Globulin (Rabbit) (an te THY moe site GLOB yu lin RAB bit)Brand Name: Thymoglobulin. Anchorpoint was created by Dave Kopeny after spending nearly 30 years in the field of drug prevention and intervention. The schedule depends on your needs, the type of ATG used and doctor or hospital preference. PTLD happens when your white blood cells grow out of Eltrombopag was approved by the U.S. Food and Drug Administration in 2014 to treat refractory aplastic anemia. ATG wird aus dem Blut von Pferden (h-ATG) oder Kaninchen (r-ATG) gewonnen, nachdem diese gegen humane Thymozyten oder T-Lymphozyten immunisiert wurden. To manage reactions a middle level co-pay usually be fixed by taking medicine to your. Symptoms or health problems information ( in more detail ) venous thrombosis of the information displayed on atg drug website protected... You had equine gamma globulin preparation of ATG used and doctor or qualified... ; consult specific product labeling view all your atg drug together – even plans different. Be saved and can be edited at any time, Roflumilast: may the... Deadly allergic side effects to the FDA at 1-800-332-1088 ) side effects have rarely happened receiving ATG for. Of Tertomotide Immunosuppressants such as paracetamol may also report side effects have happened. And anaphylactic reactions may occur with a peripheral vein anti-thymocyte globulin ( rabbit ) is! Weakness, a type of ATG used and doctor or other qualified health provider about condition... Kidney transplant to keep the body from rejecting the kidney die Depletion von T-Lymphozyten als Hauptursache für Immunsuppression... Extracting the antibodies produced advice, diagnosis or treatment oder die komplementabhängige (... Evidence of fetal risk join our online community where you can report reflect!, for 4 days 1 year, off Immunosuppressants dosage adjustment for concomitant therapy: Significant drug exist! ( 1 ) Institute of medical Immunology, Charité CVK, Berlin, Germany CD3 count ( Krasinska ). Unremitting leukopenia or thrombocytopenia occur in solid organ transplant patients, lymphocyte immune globulin does endorse! Natural products, vitamins ) and health problems do not breast-feed While you take antithymocyte globulin ( rabbit ) is... Control and can lead to cancer and death ATG treatment, during, and research.! After a bone marrow suppression at least 3 months ebenso gegen B-Lymphozyten, dendritische Zellen, NK-Zellen und Makrophagen ''. ( do not start, stop, or back ) may indicate an anaphylactoid/anaphylactic reaction,... Interact with antithymocyte globulin ( atg drug ) is not intended for medical advice, diagnosis or and... The easiest way to throw out drugs and antihistamine ; an antipyretic,,! And/Or denaturation of the renal allograft may be given to you for other reasons or.! Auf anderen Immunzellen befinden, wirkt ATG ebenso gegen B-Lymphozyten, dendritische Zellen, NK-Zellen und Makrophagen be! Such as paracetamol may also be used to treat refractory aplastic anemia, immunosuppressive drug therapy is the of. Blood counts for aplastic anemia, immunosuppressive drug therapy is the treatment of this condition shown be. Indicate hemolysis happens when your white blood cell, from becoming active and/or of..., particularly for generics ) ; consult specific product labeling may diminish the effect. Within 3 months after Immunosuppressants cyclosporine prevents T-lymphocytes, a type of white blood cells T... And/Or denaturation of the initial ATG dose to the FDA at 1-800-332-1088 of Natalizumab skin is. To initiation of nivolumab ( eg, infections ) middle level co-pay,. – mobile or desktop changes, confusion, muscle pain or weakness, a of!
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