Stem Cells. Bone Marrow Aspirate Concentrate (BMAC) Inmune diseases such as Rheumatoid arthritis, gout or pseudogout arthritis, psoriasis. Mesenchymal stem cells (MSC) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation. Background: Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. Adipose Derived Stem Cells: Adipose tissue is obtained via liposuction or lipoaspiration. A randomized non blind clinical trial with active control. The higher numbers of cells in fat leads to better clinical outcomes. A stem cell transplant can be referred to as a bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) or umbilical cord blood transplantation (UCBT), depending on the source of the cells that are transplanted. A total of 54 patients with the diagnosis of knee OA grade II and III will be recruited to receive a single intra-articular injection of MSC: Group 1 (n 18 patients) will receive BM-MSC, Group 2 (n 18 patients) will receive AD-MSC. A total of 54 patients with the diagnosis of knee OA grade II and III will be recruited to receive a single intra-articular injection of MSC: Group 1 (n 18 patients) will receive BM-MSC, Group 3 (n 18 patients) will receive AD-MSC. These cells are taken from your own tissue, so the security is very high and the possibility of rejection is almost non-existent. Once retrieved from the body, the stem cells are implanted into the patient precisely at the point of injury. derived stem cell therapy versus bone marrow aspirate stem cell therapy for any musculoskeletal disease or injury. These cells are taken from the patient’s own adipose (fat) tissue by performing a mini-liposuction procedure under local anesthetic. MSCs can be isolated from a variety of tissues, such as umbilical cord, bone marrow, and adipose tissue. It’s important to note, however, that more extensive testing is needed to confirm exactly how and why stem cell therapies work. Two of the most common types of stem cells utilized in regenerative medicine today is bone marrow and adipose stem cells for the treatment of painful musculoskeletal conditions. CD34+ regenerative cells are present with each cell type. Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N, Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Many doctors consider bone marrow stem cells as the preferred stem cell for orthopedic injuries due to the improved focus of the bone marrow stem cells toward skeletal healing. Omnihospital., Universidad Catolica Santiago de Guayaquil. In the treatment of conditions like osteoarthritis or other degenerative ailments that affect cartilage, stem cells from bone marrow could help the body grow new cells to replace damaged ones. They’ve shown incredible promise in the areas of tissue regeneration and pain mitigation. We're living in a time where multiple exciting advances have been made across the fields of science, technology, and medicine. The Mayo Clinic describes stem cells as “the body’s raw materials.” They are capable of multiplying indefinitely to become any type of cell. Imagine a substance used in the construction of a building that is able to become steel, concrete, or even glass. Universidad Catolica Santiago de Guayaquil. They divide to form many kinds of cells—blood, bone, heart, or muscle, for example—through a process called differentiation. For this purpose, the random number generator is 54, found on the RANDOM.ORG ® website (available at https://www.random.org/integers/). There are definite benefits that have been reported with both types of cells and there are similarities and differences between these two types of cells. Bone marrow and Stromal vascular factor from adipose mesenchymal stem cells 5 cc each one, by intra articular injection once. Why Should I Register and Submit Results? Most people at least know what a stem cell is, but they usually aren’t sure of the specifics. Osteoarthritis Cartilage. Evidence suggests that stem cells retrieved from bone marrow support the growth of stable joint cartilage. At that point, mobility becomes extremely limited, and replacement surgery may be the only option. However, different studies comparing ASCs and BMSCs have shown conflicting results. A randomized non blind clinical trial with active control. Bone marrow MSC’s have been used to safely treat various conditions with positive results. Peeters CM, Leijs MJ, Reijman M, van Osch GJ, Bos PK. 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