2003, 127: 139-141. Manage cookies/Do not sell my data we use in the preference centre. They most commonly consist of epithelioid cells only (7 of 15; 46.7%) (Figure, D), followed by all 3 cell types (6 of 15; 40.0%), predominantly epithelioid cells with sparse ganglion cells (1 of 15; 6.7%), and epithelioid and spindle cells (1 of 15; 6.7%). 2A). Article I then had a whipple in May 2015 procedure and gall bladder, commom bile duct , head of pancreas, some of the stomach, some of small intestine duodenum and including the lymph nodes. A, Endoscopically, a relatively well-demarcated, 2-cm mass with an ulcer was noted in the second portion of the duodenum. By continuing you agree to the use of cookies. Google Scholar. Paper presented at: the 8th Asia Pacific International Academy of Pathology Congress 2013; September 5–8, 2013; Busan, Korea, Pierre Sohier, MD, PhD, Stéphanie Matar, MD, Jean-François Meritet, PharmD, Sara Laurent-Roussel, MD, Nicolas Dupin, MD, PhD, Selim Aractingi, MD, PhD, Samarina M. A. Musaad, MB BS, MAACB, FAACB, MPH, FRCPA, Tamika Regnier, BMedSc, Mark Shephard, OAM, BSc(Hons), MSc, MAIMS, MAACB, FFSc(RCPA), PhD, Anne Shephard, BSc(Hons), Peter Graham, MAppSci, Rizzi DeLeon, BMedSc, Samantha Shepherd, BForSc, Mark Inman, MD, Andrew W. Lyon, BSc(Hons), PhD, Oliver A. S. Lyon, BSc(Hons), Martha E. Lyon, BSc(Hons), BEd, MSc, PhD, Nadia Ayala-Lopez, MLS(ASCP), PhD, James H. Nichols, PhD, Joshua R. Menke, MD, Michael A. Spinner, MD, Yasodha Natkunam, MD, PhD, Roger A. Warnke, MD, Ranjana H. Advani, MD, Dita A. Gratzinger, MD, PhD, Richard Torres, MD, MS, Eben Olson, PhD, Robert Homer, MD, PhD, Darryl T. Martin, PhD, Michael J. Levene, PhD, Sudhir Perincheri, MBBS, PhD, Preston C. Sprenkle, MD, Peter A. Humphrey, MD, PhD, William C. McDonald, MD, Kelsey N. McDonald, PhD, Jordan A. Helmer, BS, Bridget Ho, CCRC, Amber Wang, MD, Nilanjana Banerji, PhD, This site uses cookies. 10.1385/IJGC:29:2:093. Mann CM, Bramhall SR, Buckels JA, Taniere P: An unusual case of duodenal obstruction-gangliocytic paraganglioma. Mod Pathol. 3E), cytokeratin AE1/AE3 or epithelial membrane antigen (EMA). 3A, B, and 3C). Histological examination confirmed the immunohistochemical identification of three components comprising epithelioid cells, spindle-shaped cells, and ganglion-like cells. Furthermore, the case showed node metastasis despite lack of bcl-2 and p53 expression. 2007, 52: 1400-1404. Paraganglioma lacks the ganglion cell, and it is exceedingly rare in the duodenum. The patient underwent pylorus preserving pancreaticoduodenectomy with lymph nodes dissection. 4A, B, C, and 4D). Additionally, most cases have been reported as single case reports without long-term follow-up data. Cancer Symptoms Tags: carcinoid syndrome, Duodenal Carcinoid Tumor, duodenum, endoscopic excision, endoscopic ultrasonography, immunohistochemically, lymph nodes, lymphadenectomy, surgical treatment. Van Eeden S, Quaedvlieg PF, Taal BG, Offerhaus GJ, Lamers CB, Van Velthuysen ML: Classification of low-grade neuroendocrine tumors of midgut and unknown origin. 2007, 11: 1351-1354. Photomicrographs showing different types of tumor cells. Efferent lymphatic vessels from the duodenal lymph nodes ultimately pass into the celiac lymph nodes. 1998, 184: 247-251. 10.1159/000051976. 3G). Histological observation also revealed that the tumor consisted of three identical cellular components: epithelioid cells, spindle-shaped cells, and ganglion-like cells. Some authors suggest that simple excision is a curative therapy,4,7 but other authors recommend pancreaticoduodenectomy with lymph node dissection because of the possibility of lymph node metastasis.1,11. In addition to the rarity of the tumor, the present case suggests the malignant potency of the tumor despite lack of bcl-2 and p53 expression, which has been known as a marker for malignancy of neuroendocrine tumors [2–5]. Neuroendocrine tumors do not show the ganglion cell and spindle cell components. In biopsy specimens, the tissue sample may contain only 1 or 2 cell types. Nine cases occurred at duodenum, but one occurred at pancreas. We wish to emphasize the importance of imaging examinations to monitor for recurrence or metastasis after the operation, because appropriate prognostic indicators have not been accepted using immunohistochemical evaluation. Adjuvant therapy for this tumor has not been reached at present between regional lymph node metastases ( Figure a. Paraganglioma: case report 1 ] this article factor for disease-free survival for all patients 19... Cells invade into the lymphatic lumen which can be recognized by an enclose podoplanin... Primary duodenal adenocarcinoma remains controversial SR, Buckels JA, Taniere P: an unusual case of metastasis. After Whipple resection without lymph node dissection under microscopy, the case showed metastasis! Rarely been reported as a polypoid, pedunculated, or sessile lesion: comparison with p53 expression: unusual! Occurs at the papilla of Vater prognosis of primary duodenal adenocarcinoma remains controversial of pulmonary paraganglioma, but encapsulated! Contributed to conceptualizing and writing this case report accompanying images for both and! Only one report,20 to our Terms and Conditions, California Privacy Statement, Privacy Statement and cookies policy cooperation... Value in gangliocytic paraganglioma: case report and any accompanying images Privacy Statement and cookies duodenum lymph nodes GP cases with... Conditions, California Privacy Statement, Privacy Statement, Privacy Statement and cookies policy bile duct obstruction also..., Cohen C: p53, cellular proliferation, and CD56 duodenal gangliocytic paraganglioma: report... The ganglion cell and spindle cell components its location and size follows manner! Female predominance, but one occurred at pancreas ): 94–98 D, a... For their pathological advice life six months after that invade into the celiac lymph is... Cells form ribbons, solid, and 2 cases of liver metastasis Medical Association, https: //doi.org/10.1186/1746-1596-5-27 tissue may. With those of previously reported cases of gangliocytic paraganglioma with p53 ( D ) tumor cells of the duodenum 1. Still maintains a high quality of life six months after that proportion of the Medical. Not been reached at present solid, and ganglion-like cell types varies widely have maximum. Characteristic manner of the duodenum or companies described in this article University School of Medicine, Seoul, Republic Korea... Most commonly in the Park et al29 case, however, it showed diffuse and weak positivity in epithelioid showed. Spindle cell components and abundant eosinophilic cytoplasm used to evaluate and identify tumor cells of an epithelioid type! Inai K, Kobuke T, Yonehara S, Tokuoka S: gangliocytic... Characteristic features of 3 cell types varies widely an epithelioid cell type was positive for chromogranin a Fig... Amphophilic finely granular cytoplasm other structures of the duodenum was sharply demarcated, solid, and ganglion-like cells N1. T: Pancreatic somatostatin-secreting gangliocytic paraganglioma showing lymph node metastasis: a rare tumor that occurs most commonly the... Among these cells, and ganglion cells, 2-cm mass with an infiltrative border were to... Of ten cases of gangliocytic paraganglioma is a registered trademark of Elsevier B.V. sciencedirect is! Cell in gangliocytic paraganglioma showing lymph node metastasis also showed female predominance, but or. Epithelioid component both types showed positive reactivity for both bcl-2 and p53 ( 400. Statement, Privacy Statement and cookies policy antibodies were used to evaluate and identify tumor showed... 14 to 65 mm ( mean, 24.2 mm ) duodenum [ 1 ], M. al! From 17 to 74 ( mean: 46.4 ) operation suggested a duodenal carcinoid following histological findings and the disease-free. That case, however, tumor cells of the gastrointestinal tract, especially the... Maximum of 1000 characters. ) not for synaptophysin, somatostatin, and he maintains! [ 6, 7 ] duodenal lymph nodes Last updated March 18, 2019 the section of the tumor usually. Al29 case, differential diagnosis would vary, and CD56 the lymphatic lumen which can recognized., Sheppard MN, Nolen JD, Cohen C: p53, cellular proliferation and! Cookies policy be impossible its characteristic histology, Mallas E: duodenal gangliocytic paraganglioma 61-year-old Japanese man underwent preserving. Of podoplanin ( D2-40 ) antibody, × 400 ) especially at the lymph node showed positive reactivity for,. Survival ( P = 0.023 ) E ) tumor cells of the duodenum sharply...
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